Key result
Rotation of Coxsackie A-21 infected HEp-2 cultures accelerated cytopathic effects compared to stationary cultures, although total virus production was similar in both systems.
Rotation of HEp-2 tissue cultures infected with Coxsackie A-21 virus accelerates the appearance of cytopathic effects compared to stationary cultures.
No immediate clinical implications from this in vitro observation; leaves open optimized culture methods for faster viral detection in research.
Rotation of HEp-2 tissue cultures infected with Coxsackie A-21 virus enhanced the production and rapidity of appearance of CPE. In comparable stationary cultures the formation of CPE was delayed and often it was not demonstrable. Although the rate of virus replication was slightly faster in the rotated cultures the amounts of virus produced in both systems were similar.
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Mufson et al. (1962) studied this question. Rotation of Coxsackie A-21 infected HEp-2 cultures accelerated cytopathic effects compared to stationary cultures, although total virus production was similar in both systems.
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