Key result
Heparin-only stent coating reduces in vitro platelet adhesion to ~8% versus uncoated stents.
Why the study?
Does heparin coating of stents reduce platelet adhesion compared to uncoated stents in an in vitro model?
Does heparin coating of stents reduce platelet adhesion compared to uncoated stents in an in vitro model?
Heparin coating of stents is highly effective at reducing platelet adhesion in vitro, suggesting a potential mechanism to reduce vessel occlusion and restenosis.
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May warrant preclinical testing of heparin-coated stents; leaves open translation to reduced thrombosis in vivo.
Bickel et al. (2001) studied Coronary stenting. Heparin-coated stents vs. Uncoated, electropolished stents was evaluated on Platelet adhesion. Stent coating with heparin alone reduced in vitro platelet adhesion to 7.7% compared to uncoated, electropolished stents, making it the most effective among the examined coatings.
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