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September 1, 1983Radiology

Selective streptokinase infusion: clinical and laboratory correlates.

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Key result

Selective intra-arterial streptokinase achieves significant lysis in ~80% of cases and provides clinical benefit.

  • n=45

Why the study?

Does selective intra-arterial infusion of streptokinase improve lysis and clinical outcomes in patients with acute peripheral arterial thromboembolic disease?

Population

n=45 patients (50 arteries) with acute peripheral arterial thromboembolic conditions.

Design

Case_series

Authors

KMK MoriJBJ J BooksteinUniversity of San DiegoDHD J Heeney

Discussion

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Overview

Hypothesis-generating for intra-arterial streptokinase in acute peripheral arterial occlusion; randomized trials needed before clinical adoption.

Study Design

Type

Observational (n=45)

Structured PICO

Does selective intra-arterial infusion of streptokinase improve lysis and clinical outcomes in patients with acute peripheral arterial thromboembolic disease?

P
Population
45 patients with acute thromboembolic conditions treated with selective intra-arterial infusions of streptokinase.
E
Exposure
Selective intra-arterial infusion of streptokinase (most common regimen: 5,000 units/hour for 24 to 48 hours) with simultaneous heparin infusion of 250 to 500 units/hour.
O
Outcome
Significant lysis and clinical benefit

Selective intra-arterial infusion of streptokinase is a moderately effective and safe technique for acute peripheral arterial thromboembolic disease, achieving high rates of lysis with an acceptable safety profile.

Cite This Study

Mori et al. (1983) conducted an observational in acute thromboembolic conditions (n=45). Selective intra-arterial infusion of streptokinase was evaluated on Significant lysis. Selective intra-arterial infusion of streptokinase achieved significant lysis in 80% of cases and clinical benefit in 74% of patients, with major hemorrhages occurring in 8%.

synapsesocial.com/papers/6aa72390fb285da3948280f4https://doi.org/10.1148/radiology.148.3.6878683
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Also Consider

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  2. 2THE INTRAVENOUS INFUSION OF THE STREPTOCOCCAL FIBRINOLYTIC PRINCIPLE (STREPTOKINASE) INTO PATIENTS 11955 · 114 citations
  3. 3BIOCHEMICAL EVALUATION OF STANDARD TREATMENT WITH STREPTOKINASE IN ACUTE MYOCARDIAL INFARCTION1972 · 22 citations
  4. 4FIBRINOLYTIC TREATMENT IN ACUTE MYOCARDIAL INFARCTION1971 · 71 citations
  5. 5Effectiveness of intravenous streptokinase on infarct size and left ventricular function in acute myocardial infarction, prospective and randomized study1987 · 19 citations