Key result
Total laryngectomy for large laryngeal paraganglioma results in no evidence of disease at 24 months.
Case Report (n=1)
Total laryngectomy was effective in treating a rare laryngeal paraganglioma, with no evidence of recurrence at 24 months.
May support total laryngectomy for rare large laryngeal paraganglioma; leaves open optimal management strategies.
The laryngeal paraganglioma (LP) is a rare neuroendocrine neoplasm which arises from paraganglionic tissue normally present in the larynx. Immunohistochemistry is essential in the differential diagnosis of the various neuroendocrine neoplasms. The study presents a case of LP arising in an otherwise healthy 30-year-old black woman. Direct laryngoscopy revealed a large mass obstructing the airway almost completely. The patient underwent a total laryngectomy. Histopathological examination showed a population of epithelioid cells arranged in round nests and balls surrounded by a delicate stroma (‘Zellballen’ pattern). The histological and immunohistochemical patterns were coherent with LP. At 24 months after excision, she shows no evidence of disease.
No takes yet. Share an insight, caveat, or question.
Mosto et al. (2005) conducted a case report in Laryngeal paraganglioma (n=1). Total laryngectomy was evaluated on Evidence of disease. Total laryngectomy for a large laryngeal paraganglioma resulted in no evidence of disease at 24 months post-excision.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: