In-hospital and 12-month follow-up outcome from the ESC-EORP EHRA Atrial Fibrillation Ablation Long-Term registry: sex differences
Key result
AF ablation in females is linked to ~68% more cardiovascular complications despite similar recurrence.
- P<0.001
- n=3,593
Why the study?
The study was conducted to compare sex differences in catheter ablation for atrial fibrillation and evaluate opportunities for improved outcomes.
Does female sex affect the safety and efficacy outcomes of atrial fibrillation catheter ablation compared to male sex?
Population
3593 patients undergoing AF catheter ablation across 104 centres in 27 European countries
Comparison
Female vs male patients
Design
Prospective, multinational registry study
Follow-up
12 months
Authors
Discussion
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Member takes
Implication
May warrant sex-specific complication monitoring after AF ablation; leaves open whether center experience modifies this association.
Study Design
Type
Observational (n=3,593)
Multicenter
Yes
Structured PICO
Does female sex affect the safety and efficacy outcomes of atrial fibrillation catheter ablation compared to male sex?
P
Population
3,593 patients (31.9% female) undergoing atrial fibrillation catheter ablation across 27 European countries, followed for 12 months to assess sex differences in outcomes.
E
Exposure
Atrial fibrillation catheter ablation in female patients
C
Comparator
Atrial fibrillation catheter ablation in male patients
O
Outcome
In-hospital cardiovascular complications and 12-month AF recurrence ratehard clinical
Main Result
Absolute Event Rate: 5.7% vs 3.4%
p-value: p=<0.001
Women undergoing atrial fibrillation ablation have similar 12-month recurrence rates to men but experience significantly higher rates of cardiovascular complications, particularly in less experienced centers.
Cite This Study
Grecu et al. (2019) conducted an observational in Atrial fibrillation (n=3,593). Female sex vs. Male sex was evaluated on Overall cardiovascular complications (p=<0.001). Female patients undergoing atrial fibrillation catheter ablation had higher rates of overall cardiovascular complications than males (5.7% vs. 3.4%; P<0.001), with similar 12-month AF recurrence.