Key result
Fragmented QRS shows no association with CRT response in non-ischemic dilated cardiomyopathy.
Why the study?
Identifying suitable heart failure patients for CRT is difficult, prompting investigation into whether fQRS can predict response to CRT in nonischemic dilated cardiomyopathy.
Does the presence of fragmented QRS predict response to cardiac resynchronization therapy in patients with nonischemic dilated cardiomyopathy?
Observational (n=56)
No
Does the presence of fragmented QRS predict response to cardiac resynchronization therapy in patients with nonischemic dilated cardiomyopathy?
The presence of fragmented QRS on baseline ECG does not predict clinical or echocardiographic response to cardiac resynchronization therapy in patients with nonischemic dilated cardiomyopathy.
Does not support using fragmented QRS to predict CRT response in non-ischemic cardiomyopathy; hypothesis-generating and requires prospective validation.
Introduction: Cardiac resynchronization therapy (CRT) is an effective treatment in heart failure however; identifying the suitable patients is difficult.Fragmented QRS (fQRS) complex is a myocardial conduction abnormality that indicates myocardial scar.This study was conducted to find out the response of nonischemic dilated cardiomyopathy (NCMP) to CRT by using fQRS.Methods: 56 patients were enrolled.32 patients had fQRS (57.1%) and 24 had no fQRS (46.9%) on electrocardiography (ECG).All patients were suitable for CRT treatment.The two groups (fQRS and no fQRS) were evaluated before and after (1 year) CRT by using clinical status, ECG, and echocardiographic parameters.Continuous parameters were compared with Paired Samples T-test.Results: During the follow-up period; comparison of QRS (p=0.46,p=0.61), and NYHA class (p=0.29,p=0.57) were not statistically significant before and after CRT, respectively (fQRS and no fQRS).In addition, the change in left ventricular ejection fraction is not statistically significant (p=0.12).Conclusion: fQRS presence is not associated with CRT response in patients with NCMP.
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Küp et al. (2022) conducted an observational in Non-ischemic dilated cardiomyopathy (n=56). Fragmented QRS (fQRS) vs. Non-fragmented QRS was evaluated on Change in left ventricular ejection fraction (LVEF) (p=0.12). The presence of fragmented QRS on electrocardiography was not associated with a significant difference in response to cardiac resynchronization therapy in patients with non-ischemic dilated cardiomyopathy.
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