Key result
Lower exercise capacity (peakVO2 < 14 ml/min/kg) in patients with stable old myocardial infarction was associated with a steeper VCO2-VE slope compared to healthy men (37.1 vs 25.8 x 10^-3).
Why the study?
The relationship between exercise capacity and ventilatory response in patients with stable old myocardial infarction was evaluated to improve assessment methods.
Does the ventilatory equivalent for carbon dioxide (VCO2-VE slope) correlate with exercise capacity in patients with stable old myocardial infarction?
Cross-Sectional (n=91)
Does the ventilatory equivalent for carbon dioxide (VCO2-VE slope) correlate with exercise capacity in patients with stable old myocardial infarction?
The slope of the linear regression line between VCO2 and VE during submaximal exercise can be used to assess exercise capacity in patients with stable old myocardial infarction, offering an alternative when maximal exercise testing is difficult.
Steep VCO2-VE slope may mark low exercise capacity in stable old MI; leaves open its utility as submaximal alternative pending prospective validation.
The aim of the present study was to evaluate the relationship between exercise capacity and ventilatory response in patients with stable old myocardial infarction. We performed cardiopulmonary exercise test in 61 patients with stable old myocardial infarction and in 30 healthy men. Each subject exercised on a bicycle ergometer until exhaustion. Patients who had anginal pain or electrocardiographic ischemic changes during exercise were excluded. The patients were classified into three groups according to peakVO2 achieved during exercise, using Weber's method: group A, peakVO2 > or = 21 ml/min/kg (n = 4); group B, 14 < or = peakVO2 < 21 ml/min/kg (n = 45); and group C, peakVO2 < 14 ml/min/kg (n = 12). With progressive increases in VCO2, VE increased linearly below the anaerobic threshold (AT) level. The slope of the linear regression line between VCO2 and VE (SLOPE) was calculated in each subject. The mean SLOPE of the healthy men (group N) and groups A, B and C were 25.8 +/- 0.5, 25.1 +/- 0.5, 28.9 +/- 0.8 and 37.1 +/- 1.7 (x 10(-3), respectively. Thus, the SLOPE was steeper in patients with lower peakVO2. It is difficult to perform a maximal exercise tolerance test on patients with chronic heart failure to evaluate their exercise capacity. We can assess exercise capacity by the slope of the linear regression line between VCO2 and VE (SLOPE) at the lower exercise level.
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Kimura et al. (1999) conducted a cross-sectional in stable old myocardial infarction (n=91). Lower exercise capacity (peakVO2) vs. Healthy men and patients with higher peakVO2 was evaluated on Slope of the linear regression line between VCO2 and VE. Lower exercise capacity (peakVO2 < 14 ml/min/kg) in patients with stable old myocardial infarction was associated with a steeper VCO2-VE slope compared to healthy men (37.1 vs 25.8 x 10^-3).
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