What does this research mean for the field?

A 50 Hz electric leakage current via a ventricular catheter has a minimum fibrillation threshold of 130 µA in dogs, which is lowered to 100 µA by severe metabolic acidosis but unaffected by hypoxaemia. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

Determine the minimum electrical leakage current required to induce ventricular fibrillation via intracardiac catheters under baseline physiological conditions, metabolic acidosis, and hypoxaemia.

July 1, 1973Cardiovascular Research

Thresholds of fibrillating leakage currents along intracardiac catheters: an experimental study

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Key result

Severe metabolic acidosis lowers the catheter-induced ventricular fibrillation threshold by ~23% in dogs.

Why the study?

The effect of metabolic conditions on fibrillation thresholds induced by intracardiac catheter leakage currents was not well characterized.

Population

Dogs with normal acid-base and cation state

Comparison

Normal acid-base state vs severe metabolic acidosis vs hypoxaemia

Design

Experimental study

Authors

WLW. Robert LeeStatens Serum Institut JSJohn R. ScottDalhousie University

Discussion

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Implication

May warrant caution with intracardiac devices during acidosis; leaves open human translation.

Key Points

Determine the minimum electrical leakage current required to induce ventricular fibrillation via intracardiac catheters under baseline physiological conditions, metabolic acidosis, and hypoxaemia.
Delivered a 50 Hz electric shock between an intracardiac ventricular catheter and the right leg in canine models.
Assessed electrical fibrillation thresholds under normal acid-base balance, severe metabolic acidosis, and hypoxaemic states.
Baseline minimum ventricular fibrillation threshold was 130 µA during normal acid-base and cation states.
Severe metabolic acidosis decreased the ventricular fibrillation threshold to 100 µA.
Hypoxaemia produced no measurable effect on the current threshold required to trigger fibrillation.

Cite This Study

Lee et al. (1973) studied this question. A 50 Hz electric shock passed through a ventricular catheter has a minimum fibrillation threshold of 130 uA in dogs, which decreases to 100 uA during severe metabolic acidosis.

synapsesocial.com/papers/6aa916e97cd5a4625c5d5458 https://doi.org/10.1093/cvr/7.4.495

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Thresholds of fibrillating leakage currents along intracardiac catheters: an experimental study

Discussion

Member takes

Implication

Key Points

Cite This Study

Thresholds of fibrillating leakage currents along intracardiac catheters: an experimental study

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

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