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November 1, 1978AJP Heart and Circulatory Physiology

Temporal stability and precision of ventricular defibrillation threshold data

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Why the study?

Is the ventricular defibrillation threshold a stable and precise physiological parameter over time in anesthetized dogs?

Population

15 pentobarbital-anesthetized dogs

Design

Preclinical

Follow-up

Up to 8 hours

Authors

CBCharles F. BabbsPurdue University West LafayetteSWS.J. WhistlerPurdue University West LafayetteGYG.K.W. YimNorthwestern University

Discussion

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Implication

Defibrillation threshold remains stable in anesthetized dogs; leaves open translation to clinical settings.

Structured PICO

Is the ventricular defibrillation threshold a stable and precise physiological parameter over time in anesthetized dogs?

P
Population
15 pentobarbital-anesthetized dogs
I
Intervention
Repeated trials of fibrillation and defibrillation with successive shocks of diminishing current (transchest electrical ventricular defibrillation)
O
Outcome
Stability and precision of ventricular defibrillation threshold (minimum damped sinusoidal current and energy)surrogate

Ventricular defibrillation threshold is a stable physiological parameter that can be measured with reasonable precision over time in an animal model.

Cite This Study

Babbs et al. (1978) studied this question.

synapsesocial.com/papers/6a70593b35aa2c282ce1a78ehttps://doi.org/10.1152/ajpheart.1978.235.5.h553
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Also Consider

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  1. 1Defibrillation threshold using different electrode configurations2002
  2. 2Defibrillation Threshold: A Simple and Quantitative Estimate of the Ability to Defibrillate1987 · 101 citations
  3. 3The relationship between successful defibrillation and delivered energy in open-chest dogs: Reappraisal of the “defibrillation threshold” concept1987 · 217 citations
  4. 4Internal Cardiac Defibrillation Threshold: Effects of Acute Ischemia1986 · 26 citations
  5. 5Strength‐Duration Curves of Fixed Pulse Width Variable Tilt Truncated Exponential Waveforms for Nonthoracomy Internal Defibrillation in Dogs1988 · 45 citations