Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
November 1, 1987Arteriosclerosis An Official Journal of the American Heart Association IncOpen Access

Substratum-bound elastin peptide inhibits aortic smooth muscle cell migration in vitro.

View Full Paper
Ask AI
Bookmark
Share

Key result

Filter-bound elastin peptides inhibit in vitro rat aortic SMC migration in response to platelet-derived factors.

Why the study?

Migration of aortic smooth muscle cells through the internal elastic lamina is important in atherosclerosis development, but the influence of elastin peptides on this migration was unclear.

Does substratum-bound elastin peptide inhibit the migration of cultured rat aortic smooth muscle cells in vitro?

Population

Cultured rat aortic smooth muscle cells and polymorphonuclear leukocytes in vitro

Comparison

Filters coated with elastin peptides vs filters coated with other matrix components

Design

In vitro study using modified Boyden's chamber

Authors

TOToshiro OoyamaKumamoto UniversityKFKoji FukudaAkita UniversityHOH. OdaSaitama Medical University

Discussion

Loading...

Member takes

Implication

May limit vascular smooth muscle migration in vitro; leaves open relevance to atherosclerosis in vivo.

Structured PICO

Does substratum-bound elastin peptide inhibit the migration of cultured rat aortic smooth muscle cells in vitro?

P
Population
Cultured rat aortic smooth muscle cells (SMCs) and polymorphonuclear leukocytes in vitro
I
Intervention
Filters coated with elastin peptides (substratum-bound elastin peptides)
C
Comparator
Filters coated with other matrix components (Types I, III, IV, and V collagens and fibronectin)
O
Outcome
Cell migration in a modified Boyden's chamber in response to chemoattractants (platelet-derived factors or elastin peptides in solution)surrogate

Substratum-bound elastin peptides specifically inhibit the migration of vascular smooth muscle cells in vitro, suggesting a potential natural inhibitory mechanism against atherosclerosis development.

Cite This Study

Ooyama et al. (1987) studied Atherosclerosis (in vitro model). Filter-bound elastin peptides vs. Other matrix components (collagens, fibronectin) was evaluated on Migratory response of cultured rat aortic SMCs. Filter-bound elastin peptides specifically inhibited the in vitro migration of cultured rat aortic smooth muscle cells in response to platelet-derived factors.

synapsesocial.com/papers/6aa93cd8c924504423cdca0fhttps://doi.org/10.1161/01.atv.7.6.593
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Endothelin-1 induces pulmonary but not aortic smooth muscle cell migration by activating ERK1/2 MAP kinaseThis article is one of a selection of papers published in the two-part special issue entitled 20 Years of Endothelin Research.2010 · 29 citations
  2. 2Effect of platelet factors on migration of cultured bovine aortic endothelial and smooth muscle cells.1989 · 130 citations
  3. 3Primate Smooth Muscle Cell Migration From Aortic Explants Is Mediated by Endogenous Platelet-Derived Growth Factor and Basic Fibroblast Growth Factor Acting Through Matrix Metalloproteinases 2 and 91997 · 146 citations
  4. 4Physiological Impact of a Synthetic Elastic Protein in Arterial Diseases Related to Alterations of Elastic Fibers: Effect on the Aorta of Elastin-Haploinsufficient Male and Female Mice2022 · 2 citations
  5. 5ELASTIN EXPRESSION IN A MODEL OF ACUTE ARTERIAL GRAFT REJECTION1994 · 20 citations