Key result
A newly identified third pathway for high diastolic left ventricular stiffness in a mouse model expands known mechanisms beyond fibrosis and titin rigidification.
Highlights a newly discovered third mechanism for high diastolic left ventricular stiffness in heart failure based on a mouse model.
There are two established causes of high diastolic left ventricular stiffness: fibrosis and the rigidification of titin. A recent scientific study of a mouse model points to a third path, with implications for new experimental strategies.
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Walter J. Paulus (2020) studied this question. A newly identified third pathway for high diastolic left ventricular stiffness in a mouse model expands known mechanisms beyond fibrosis and titin rigidification.
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