Key result
Systemic hypertension reduces glomerular proteinase activity and cathepsin B in unclipped kidneys of Goldblatt rats.
Why the study?
The pathogenetic mechanism underlying the development of glomerulosclerosis due to systemic hypertension has not been completely resolved, with a potential role for decreased glomerular proteinase activity.
Does systemic hypertension decrease glomerular proteinase activity in Goldblatt rats?
Population
Goldblatt hypertensive rats
Comparison
Unclipped kidney exposed to systemic hypertension vs contralateral clipped kidney and sham-operated normotensive controls
Design
Preclinical experimental study
Follow-up
20 weeks
Authors
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May implicate reduced proteinase activity in hypertensive glomerulosclerosis; leaves open relevance to human disease and therapy.
Does systemic hypertension decrease glomerular proteinase activity in Goldblatt rats?
Systemic hypertension in Goldblatt rats is associated with decreased glomerular proteinase activity, suggesting a biochemical mechanism contributing to glomerulosclerosis.
Pączek et al. (1991) studied Systemic hypertension and glomerulosclerosis. Systemic hypertension (unclipped kidney) vs. Contralateral clipped kidney and sham-operated normotensive controls was evaluated on Glomerular proteinase activity and cathepsin B-content. In Goldblatt rats, the unclipped kidney exposed to systemic hypertension showed reduced glomerular proteinase activity and decreased cathepsin B-content compared to controls.
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