Why the study?
Does daily intraperitoneal proteolytic enzyme administration reduce hypertension-induced renal injury in a rat model of Goldblatt hypertension?
Population
21 Male Wistar rats, including 16 with 2-kidney 1-clip Goldblatt hypertension and 5 sham surgery controls.
Comparison
Intraperitoneal daily administration of a fixed… vs Intraperitoneal daily administration of vehicle…
Design
Preclinical, randomized into 2 groups
Follow-up
7 weeks
Authors
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Preclinical renoprotection without BP change in rats; leaves open translation to human renovascular hypertension.
Does daily intraperitoneal proteolytic enzyme administration reduce hypertension-induced renal injury in a rat model of Goldblatt hypertension?
Systemic treatment with proteolytic enzymes ameliorates nephrosclerosis and proteinuria in a rat model of renovascular hypertension without lowering blood pressure.
Šebeková et al. (1998) studied this question.
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