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January 12, 2021British journal of surgery

Impact of early biochemical diagnosis of anastomotic leakage after rectal cancer surgery: long-term results from GRECCAR 5 trial

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Key result

Early CRP-guided diagnosis and intervention for anastomotic leakage mitigates adverse oncological outcomes in rectal cancer.

Why the study?

Does early biochemical diagnosis of anastomotic leakage improve oncological outcomes in patients with rectal cancer?

Population

Patients with rectal cancer

Authors

QDQuentin DenostPRPhilippe RouanetJFJean‐Luc Faucheron

Discussion

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Member takes

Overview

May support CRP surveillance for early AL in rectal cancer; leaves open oncological benefit confirmation in randomized trials.

Structured PICO

Does early biochemical diagnosis of anastomotic leakage improve oncological outcomes in patients with rectal cancer?

P
Population
Patients with rectal cancer
I
Intervention
Early biochemical diagnosis (using elevated C-reactive protein) and intervention of anastomotic leakage (AL)
O
Outcome
Oncological outcomes

Early biochemical diagnosis of anastomotic leakage using C-reactive protein mitigates its negative impact on oncological outcomes in rectal cancer patients.

Cite This Study

Denost et al. (2021) studied this question. Early biochemical diagnosis and intervention of anastomotic leakage using elevated C-reactive protein mitigates its negative impact on oncological outcomes in patients with rectal cancer.

synapsesocial.com/papers/6aaa4cc57c146daf1bf28767https://doi.org/10.1093/bjs/znab003
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Early and late symptomatic anastomotic leakage following low anterior resection of the rectum for cancer: are they different entities?2012 · 67 citations
  2. 2Influence of Conversion and Anastomotic Leakage on Survival in Rectal Cancer Surgery; Retrospective Cross-sectional Study2018 · 37 citations
  3. 3Systemic and local inflammation in colorectal cancer2019 · 18 citations
  4. 4Anastomotic leakage after curative anterior resection results in a higher prevalence of local recurrence2003 · 322 citations
  5. 5Systemic immune-inflammation index for predicting prognosis of colorectal cancer2017 · 755 citations