Key result
Perfusion-metabolism mismatch in ~24% of incident dialysis patients links to higher PTH, albumin, and alkaline phosphatase.
Why the study?
Little is known about the pathogenesis of cardiovascular disease in incident dialysis patients without ischemic heart disease.
Does BMIPP and myocardial perfusion imaging identify perfusion-metabolism mismatch associated with uremic cardiomyopathy in incident hemodialysis patients without ischemic heart disease?
Population
42 incident dialysis patients without histories of ischemic heart disease
Comparison
BMIPP-positive patients with perfusion-positive vs perfusion-negative findings
Design
Cross-sectional study
Authors
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May signal mineral bone disorder effects on myocardium at dialysis start; hypothesis-generating and should not change practice.
Cross-Sectional (n=42)
Does BMIPP and myocardial perfusion imaging identify perfusion-metabolism mismatch associated with uremic cardiomyopathy in incident hemodialysis patients without ischemic heart disease?
A perfusion-metabolism mismatch on SPECT imaging is present in some incident dialysis patients without ischemic heart disease and is associated with elevated PTH, suggesting the presence of uremic cardiomyopathy.
Koyama‐Nakamura et al. (2015) conducted a cross-sectional in Incident dialysis without ischemic heart disease (n=42). Perfusion-metabolism mismatch vs. BMIPP- and perfusion-positive patients was evaluated on Parathyroid hormone (PTH), serum albumin, and alkaline phosphatase levels. Perfusion-metabolism mismatch occurred in 10 of 42 incident dialysis patients without ischemic heart disease and was associated with higher parathyroid hormone, albumin, and alkaline phosphatase.
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