Key result
Preoperative pregabalin cuts intraoperative isoflurane requirements ~36% versus placebo during elective abdominal hysterectomy.
Why the study?
Preoperative oral pregabalin controls postoperative pain and decreases anesthetic requirements in total intravenous anaesthesia, leading investigators to hypothesize that it reduces inhaled isoflurane requirements.
Does preoperative oral pregabalin reduce inhaled isoflurane requirements in women undergoing elective abdominal hysterectomy?
RCT (n=50)
Double-blind
computer-generated random number table
No
Does preoperative oral pregabalin reduce inhaled isoflurane requirements in women undergoing elective abdominal hysterectomy?
Preoperative oral pregabalin 150 mg significantly reduces inhaled isoflurane requirements and improves postoperative analgesia in women undergoing elective abdominal hysterectomy.
Pregabalin 150 mg preoperatively lowers isoflurane needs in hysterectomy; extends RCT evidence for its anesthetic-sparing role in gynecologic surgery.
Background: preoperative oral pregabalin controls postoperative pain & decreases anesthetic requirements in total intravenous anaesthesia . In this study, we hypothesized that preoperative pregabalin reduces inhaled isoflurane requirements. Methods: Study was conducted in a university hospital, included 50 women (18-60 yrs.), ASA I or II, admitted to undergo elective abdominal hysterectomy under general anaesthesia. Time of study: June to September 2017. Exclusion criteria were allergy or hypersensitivity to pregabalin; patients on calcium channel blockers, antiepileptic drugs, antidepression drugs, any analgesics or sedatives, or oral hypoglycemic agents; and patients with severe cardiovascular, renal, hepatic or neurological dysfunction. Interventions: giving either oral pregabalin 150 mg or placebo to patients of both groups. Primary outcome measures: inhaled isoflurane requirements to maintain haemodynamics ± 20% of baseline& bispectral index (BIS) of 40 - 60, measured using MAQUET Flow-I anaesthetic machine. Secondary outcomes : attenuation of pressor response to intubation, postoperative pain, first time for rescue analgesia, total anaglesics and adverse effects. Results: Isoflurane consumption was significantly less in pregabalin group (7.80 ± 1.27ml h -1) versus (12.27 ± 2.49 ml h-1) in control group, (P= 0.00). Better haemodynamic stability was in pregabalin group after intubation. First postoperative hour :the mean VAS score was significantly higher in control group (7.10 ± 1.20) compared to pregabalin group (4.50 ± 1.70), P<0.001. All patients in control group received pethidine intramuscular. More patients in pregabalin group suffered dizziness. Conclusion: preoperative pregabalin 150 mg ,1 h before total abdominal hysterectomy has an inhaled anaesthetic-sparing effect, maintain haemodynamics and optimizes postoperative analgesia. Keywords: Gabapentinoids, Pregabalin; Inhalation Anaesthetics, Isoflurane; Monitoring, Bispectral Index; Surgery, Abdominal Hysterectomy Objectives: We aimed to investigate the effectiveness and safety of preoperative oral pregabalin 150 mg in women undergoing elective total abdominal hysterectomy under general anaesthesia. Design: A prospective, randomized, double-blind, controlled study. Trial Registry Number: ClinicalTrials.gov: NCT 03302208
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Mohamed et al. (2019) conducted an RCT in Elective total abdominal hysterectomy (n=50). Pregabalin vs. Placebo was evaluated on Inhaled isoflurane requirements (ml/h) to maintain haemodynamics ± 20% of baseline and bispectral index (BIS) of 40-60 (p=0.00). Preoperative oral pregabalin 150 mg significantly reduced intraoperative inhaled isoflurane requirements compared to placebo (7.80 vs 12.27 ml/h, P=0.00) in women undergoing elective abdominal hysterectomy.
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