What question did this study set out to answer?

Determine the role of the bursa of Fabricius and the thymus in conferring resistance to Salmonella typhimurium infection in chickens.

February 1, 1970Avian Diseases

Role of Bursa of Fabricius in Chicken Resistance to Salmonella typhimurium

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Authors

JBJ. R. BrownellBrooke Army Medical Center WSW. W. SadlerDepartment of Public Health MFM. J. FanelliPresidio Ospedaliero

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Implication

Controlled animal study reveals increased Salmonella clearance defects and tissue invasion in bursectomized chickens, indicating a key protective role for the bursa of Fabricius.

Key Points

Determine the role of the bursa of Fabricius and the thymus in conferring resistance to Salmonella typhimurium infection in chickens.
Surgically bursectomized, thymectomized, and intact control chickens received Salmonella typhimurium via intraperitoneal, intrarectal, or oral administration.
Infection severity was evaluated by measuring bacterial counts in abdominal fluid at necropsy (3 to 48 hours), quantifying cecal content bacteria, and assessing cecal wall invasion via fluorescent antibody staining.
Long-term immunity was evaluated by initial oral challenge (10 or 10^8 organisms) followed by an intraperitoneal challenge (10^8 organisms) 48 days later, monitored via serial rectal swabs.
Bursectomized birds showed significantly higher Salmonella counts in abdominal fluid at 6 hours post-intraperitoneal inoculation compared with unbursectomized controls.
Fluorescent antibody imaging of cecal walls revealed significantly higher rates of tissue invasion in bursectomized birds, despite equivalent bacterial counts in cecal contents at 24 and 48 hours.
Rectal swab shedding following oral and secondary intraperitoneal challenges was significantly prolonged in bursectomized chickens, whereas thymectomized birds showed no differences from controls.

Cite This Study

Brownell et al. (1970) studied this question.

synapsesocial.com/papers/6aab48cb8ff8f3e5b98bd13a https://doi.org/10.2307/1588565

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Implication

Controlled animal study reveals increased Salmonella clearance defects and tissue invasion in bursectomized chickens, indicating a key protective role for the bursa of Fabricius.

Role of Bursa of Fabricius in Chicken Resistance to Salmonella typhimurium

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Key Points

Cite This Study

Role of Bursa of Fabricius in Chicken Resistance to Salmonella typhimurium

Discussion

Member takes

Implication

Key Points

Cite This Study

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