Key result
Adrenaline infusion drives greater diastolic BP and noradrenaline responses to cold stress in familial hypertension.
Why the study?
Differences in blood pressure and catecholamine responses to adrenaline infusion between individuals with and without a family history of hypertension were unclear.
Does a positive family history of hypertension affect blood pressure and catecholamine responses to a 6-hour adrenaline infusion in normal subjects?
Population
Normal subjects with and without family history of hypertension
Comparison
6 hour adrenaline infusion and post-infusion cold pressor test vs 6 hour dextrose infusion and post-infusion cold pressor test
Design
Comparative physiological study
Authors
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May signal early autonomic changes in at-risk individuals; leaves open whether adrenaline sensitivity predicts incident hypertension.
Does a positive family history of hypertension affect blood pressure and catecholamine responses to a 6-hour adrenaline infusion in normal subjects?
Normal subjects with a family history of hypertension exhibit altered sympathetic and blood pressure responses to adrenaline infusion and cold pressor testing compared to those without.
Bachmann et al. (1993) studied Family history of hypertension. 6-hour adrenaline infusion vs. 6-hour dextrose infusion was evaluated on Blood pressure and catecholamine responses. Adrenaline infusion caused greater plasma noradrenaline and diastolic blood pressure responses to a cold pressor test in subjects with a family history of hypertension compared to those without.
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