Key result
Type IIB hypertriglyceridemia links to ~31% higher serum sialic acid levels versus normal controls.
Why the study?
Serum total and lipid-associated sialic acid concentrations have been identified as cardiovascular risk factors, but their levels in patients with hypertriglyceridaemia showing Frederickson's IIB phenotype were not well characterized.
Are serum total and lipid-associated sialic acid concentrations elevated in patients with hypertriglyceridaemia compared to normal controls and hypercholesterolaemic patients?
Population
15 patients with hypertriglyceridaemia (Frederickson's IIB), 15 with hypercholesterolaemia (IIA), and 15 matched controls
Comparison
Hypertriglyceridaemia (IIB phenotype) vs hypercholesterolaemia (IIA phenotype) and normal controls
Design
Observational case-control study
Authors
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No immediate clinical action; leaves open sialic acid as a potential dyslipidaemia biomarker pending prospective studies.
Observational (n=45)
Are serum total and lipid-associated sialic acid concentrations elevated in patients with hypertriglyceridaemia compared to normal controls and hypercholesterolaemic patients?
Absolute Event Rate: 84.9% vs 64.9%
p-value: p=<0.03
Serum total and lipid-associated sialic acid concentrations are significantly elevated in patients with hypertriglyceridaemia (Frederickson's IIB phenotype), suggesting they may serve as markers of cardiovascular risk.
Crook et al. (1992) conducted an observational in Hypertriglyceridaemia (n=45). Hypertriglyceridaemia (Frederickson's IIB phenotype) vs. Normal controls was evaluated on Total serum sialic acid concentration (p=<0.03). Patients with type IIB hypertriglyceridaemia had significantly higher total serum sialic acid concentrations compared to normal controls (84.9 vs 64.9 mg/dl; P<0.03).
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