Key result
Intrapericardial minocycline produces pericardial cavity obliteration in ~100% of treated dogs versus saline.
Why the study?
The study aimed to evaluate whether intrapericardial instillation of tetracycline is superior to drainage alone in causing pericardial adhesions and cavity obliteration.
Does intrapericardial instillation of minocycline hydrochloride improve pericardial cavity obliteration compared to drainage alone in a dog model?
Comparison
Minocycline hydrochloride 20 mg/kg vs normal saline intrapericardial instillation
Design
Randomized controlled trial
Follow-up
1 month
Authors
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Leaves open clinical translation to human pericardial disease; hypothesis-generating for intrapericardial minocycline.
RCT (n=12)
randomly divided
Does intrapericardial instillation of minocycline hydrochloride improve pericardial cavity obliteration compared to drainage alone in a dog model?
Absolute Event Rate: 100% vs 0%
Intrapericardial instillation of minocycline hydrochloride effectively causes pericardial adhesions and cavity obliteration in a dog model, supporting its potential clinical use for persistent pericardial effusion.
Markiewicz et al. (2009) conducted an RCT in persistent pericardial effusion (dog model) (n=12). minocycline hydrochloride vs. normal saline was evaluated on over 25% cavity obliteration. Intrapericardial instillation of minocycline hydrochloride resulted in >25% cavity obliteration in 100% of treated dogs, compared to 0% in controls receiving normal saline.
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