Key result
Cilazapril decreases vascular hypertrophy and improves coronary and cerebral reserves in experimental hypertension.
Why the study?
Anatomical changes of arteries and arterioles secondary to hypertension explain most late complications, motivating characterization of cilazapril's vascular protective effects in experimental hypertension.
Does cilazapril provide vascular protection in experimental hypertension?
Does cilazapril provide vascular protection in experimental hypertension?
In experimental models, cilazapril provides broad vascular protection by reducing hypertrophy and improving vascular reserve, regardless of whether given preventively or after hypertension onset.
Answers are grounded in this paper and cite their sources.
Hypothesis-generating in hypertensive animal models; leaves open translation to human vascular protection.
Anatomical changes of arteries and arterioles secondary to hypertension explain most of the late complications of this disease. Therefore, a series of experiments was performed to characterize the vascular protective effects of cilazapril in experimental hypertension. These experiments aimed to answer three types of questions: (a) In which vascular bed is cilazapril effective? (b) Are the vascular changes induced by cilazapril associated with functional effects? (c) Is the effect of cilazapril only preventive or can cilazapril also be effective when hypertension is already present? Our results show that cilazapril is acting on nearly every vascular bed. Its vascular morphological effects (decrease of vascular hypertrophy) are associated with functional changes such as improvements of coronary or cerebral vascular reserves. Cilazapril is active either as a preventive treatment or given when hypertension is already present.
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Clozel et al. (1992) studied Experimental hypertension. Cilazapril was evaluated on Vascular morphological effects and functional changes. Cilazapril decreased vascular hypertrophy and improved coronary and cerebral vascular reserves in experimental hypertension, acting both preventively and as a treatment.
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