Key result
Immunocytochemical analysis of two laryngeal paragangliomas demonstrated positive immunoreactivity for calcitonin and vasoactive intestinal polypeptide, suggesting their multihormonal nature.
Why the study?
Paraganglionic tumors of the larynx are uncommon and their secretory products have rarely been elucidated.
Case Report (n=2)
Laryngeal paragangliomas can exhibit multihormonal characteristics, including the coexistence of amines and hormonal polypeptides.
May aid immunohistochemical workup of rare laryngeal tumors; leaves open clinical relevance pending larger series.
Paraganglionic tumors of the larynx are uncommon neoplasms and their secretory products have rarely been elucidated. We saw two patients whose laryngeal paragangliomas were examined with an electron microscope and by the use of immunocytochemical techniques. Both tumors manifested positive immunoreactivity against calcitonin and vasoactive intestinal polypeptide. One of the paragangliomas was immunoreactive against carcinoembryonic antigen and pursued a biologically malignant course. Our observations suggest the coexistence of amines and hormonal polypeptides in cells of paraganglionic tumors and demonstrate the multihormonal nature of these tumors.
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Sneige et al. (1983) conducted a case report in Laryngeal paraganglioma (n=2). Immunocytochemical and ultrastructural analysis was evaluated on Immunoreactivity and ultrastructural characteristics. Immunocytochemical analysis of two laryngeal paragangliomas demonstrated positive immunoreactivity for calcitonin and vasoactive intestinal polypeptide, suggesting their multihormonal nature.
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