Key result
Plasma IGFBP-1 levels are discussed as a potential serum marker of insulin resistance due to the direct inhibitory influence of insulin on hepatic IGFBP-1 production.
Plasma IGFBP-1 levels are discussed as a potential serum marker of insulin resistance.
We were interested in the article of Maddux et al. (1) in which they found a correlation coefficient of 0.75 for the relationship of IGF-binding protein (IGFBP)-1 with insulin sensitivity. Often, the homeostasis model assessment of insulin resistance (HOMA-IR) or other assessments such as the Stumvoll Index (2) are used. Because hepatic production of IGFBP-1 is under direct inhibitory influence of insulin, plasma IGFBP-1 levels could potentially be of use …
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Haeften et al. (2007) conducted a letter in Insulin resistance. IGF-Binding Protein-1 (IGFBP-1) was evaluated on Insulin sensitivity. Plasma IGFBP-1 levels are discussed as a potential serum marker of insulin resistance due to the direct inhibitory influence of insulin on hepatic IGFBP-1 production.
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