Key result
Elevated circulating CTRP-3 and PEDF link to metabolic syndrome and multiple cardiometabolic risk factors.
Why the study?
The roles of circulating CTRP-3 and PEDF concentrations in patients with type 2 diabetes and metabolic syndrome and their associations with cardiometabolic risk factors were not fully elucidated.
Cross-Sectional (n=345)
Circulating CTRP-3 and PEDF concentrations are elevated in patients with metabolic syndrome and glucose dysregulation, and correlate with various cardiometabolic risk factors.
CTRP-3 and PEDF elevations may mark metabolic syndrome risk; hypothesis-generating and requires longitudinal validation before clinical adoption.
Recent studies have suggested that a novel adipokine, C1q/tumor necrosis factor-related protein-3 (CTRP-3), a paralog of adiponectin, may play an important role in the regulation of glucose metabolism and innate immunity. Pigment epithelium-derived factor (PEDF), a multifunctional protein with antioxidant and anti-inflammatory properties, is associated with insulin resistance and metabolic syndrome. We examined circulating CTRP-3 and PEDF concentrations in 345 subjects with diverse glucose tolerance statuses. Furthermore, we evaluated the involvement of CTRP-3 and PEDF with cardiometabolic risk factors including insulin resistance, high-sensitivity C-reactive protein (hsCRP), estimated glomerular filtration rate (eGFR), and brachial-ankle pulse wave velocity (baPWV). CTRP-3 concentrations were significantly higher in patients with type 2 diabetes or prediabetes than the normal glucose tolerance group, whereas PEDF levels were not different. Subjects with metabolic syndrome showed significantly higher levels of both CTRP-3 and PEDF compared with subjects without metabolic syndrome. Both CTRP-3 and PEDF were significantly associated with cardiometabolic parameters, including waist-to-hip ratio, triglycerides, HDL-cholesterol, alanine aminotransferase, eGFR, hsCRP, and baPWV. In conclusion, circulating CTRP-3 concentrations were elevated in patients with glucose metabolism dysregulation. Both CTRP-3 and PEDF concentrations were increased in subjects with metabolic syndrome and associated with various cardiometabolic risk factors.
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Choi et al. (2012) conducted a cross-sectional in Type 2 Diabetes and Metabolic Syndrome (n=345). Glucose metabolism dysregulation and metabolic syndrome vs. Normal glucose tolerance and absence of metabolic syndrome was evaluated on Circulating CTRP-3 and PEDF concentrations. Circulating CTRP-3 and PEDF concentrations were significantly increased in subjects with metabolic syndrome and associated with various cardiometabolic risk factors.
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