Key result
Echocardiographic assessment of male mice after acute myocardial infarction showed deterioration of LV function and development of LV dilation, which did not develop in all subjects.
First open-access murine post-MI remodeling dataset; leaves open translation to human systems approaches.
Open-access datasets for cardiac remodelling after myocardial infarction in any species have not been reported, and this limits the development of systems approaches in medicine.In this paper, we present a dataset from echocardiographic assessment of male C57BL mice that were subjected to acute myocardial infarction.We present measurements that show the deterioration of global left ventricular (LV) function, regional function, development of LV dilation and hypertrophy.At the same time, we present measurements showing the degree of cardiac injury as well as the development of pulmonary congestion.Importantly, LV dilation-a hallmark of cardiac remodelling-does not develop in all subjects, and this is only partly explained by the degree of cardiac injury.
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Mourouzis et al. (2015) studied Acute myocardial infarction. Acute myocardial infarction was evaluated on Echocardiographic assessment of cardiac function, LV dilation, and hypertrophy. Echocardiographic assessment of male mice after acute myocardial infarction showed deterioration of LV function and development of LV dilation, which did not develop in all subjects.
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