Key result
Novel orally potent human renin inhibitor containing cyclohexylnorstatine achieves successful synthesis.
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Design
Design and synthesis of a novel human renin inhibitor
May inform oral renin inhibitor development; leaves open clinical translation of cyclohexylnorstatine analogs.
An orally potent human renin inhibitor (1a) containing a novel amino acid, (2R,3S)-3-amino-4-cyclohexyl-2-hydroxybutyric acid named cyclohexylnorstatine, has been designed from the angiotensinogen transition-state and synthesized.
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Iizuka et al. (1989) studied this question. An orally potent human renin inhibitor containing the novel amino acid cyclohexylnorstatine was successfully designed from the angiotensinogen transition-state and synthesized.
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