Key result
CABG linked to ~8.5% LVEF improvement at 15 days in severe ischemic LV dysfunction.
Why the study?
The impact of CABG on improvement in LVEF among patients with severe LV dysfunction was assessed to understand its beneficial effects.
Does CABG improve LVEF in patients with severe ischemic LV dysfunction?
Observational (n=134)
No
Does CABG improve LVEF in patients with severe ischemic LV dysfunction?
Mean Difference: 8.5 (95% CI 8–8.9)
Absolute Event Rate: 32.11% vs 23.63%
p-value: p=<0.001
Surgical revascularization with CABG significantly improves left ventricular ejection fraction in patients with severe ischemic LV dysfunction at short-term follow-up.
CABG was associated with short-term LVEF gains in severe ischemic LV dysfunction; hypothesis-generating and requires randomized confirmation of durability.
Objectives: To assess the improvement in left ventricular ejection fraction (LVEF) after Coronary artery bypass grafting (CABG) among patients with severe LV dysfunction. Methodology: This Quasi experimental study was conducted at Punjab Institute of Cardiology from January to June 2021. One hundred and thirty four patients of severe LV dysfunction with coronary anatomy suitable for CABG were included in the study. Assessment of LVEF was carried out with echocardiography at baseline. All patients underwent CABG under general anaesthesia and were followed-up on 15th day with repeat echocardiography. Pre-CABG and post-CABG EFs were compared and mean changes in EFs were checked for potential effect modifications with gender, diabetes, CAD duration, age and body weight. Results: The mean LVEFs before and after surgery were 23.63 ± 1.17% and 32.11 ± 1.98% respectively. Mean improvement in LVEF after CABG was 8.5 ± 2.7 % (p < 0.001, 95% CI for difference 8.0 – 8.9) and did not different significantly according to gender, diabetes, CAD duration, age and body weight (P = 0.592, 0.167, 0.506, 0.138 and 0.458 respectively). Conclusion: Patients of CAD who underwent CABG had improved post-operative LVEFs independent of evaluated potential effect modifiers.
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Ahmed et al. (2022) conducted an observational in Severe ischemic left ventricular dysfunction (n=134). Coronary artery bypass grafting (CABG) vs. Baseline (Pre-CABG) was evaluated on Change in left ventricular ejection fraction (LVEF) (MD 8.5, 95% CI 8.0-8.9, p=<0.001). Coronary artery bypass grafting significantly improved mean left ventricular ejection fraction by 8.5% at 15 days post-surgery in patients with severe ischemic left ventricular dysfunction.
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