Key result
ACE2 CCA haplotype linked to ~47% lower risk of elevated PAP in female CHD patients.
Why the study?
The impact of ACE2 polymorphisms on pulmonary circulation in congenital heart disease patients was unclear.
Are ACE2 gene polymorphisms associated with elevated pulmonary artery pressure in patients with congenital heart disease?
Observational (n=367)
Are ACE2 gene polymorphisms associated with elevated pulmonary artery pressure in patients with congenital heart disease?
Answers are grounded in this paper and cite their sources.
ACE2 gene polymorphisms, specifically CCA and CCG haplotypes, are associated with a lower risk of pulmonary hypertension in female patients with congenital heart disease.
BACKGROUNDS: Angiotensin converting enzyme 2 (ACE2) polymorphisms are related to the occurrence and prognosis of cardiovascular disease. However, whether ACE2 polymorphisms also affect pulmonary circulation in congenital heart disease (CHD) remains unclear. Thus, we investigated the relationship between ACE2 single nucleotide polymorphism (SNPs) and pulmonary circulation in CHD patients of Chinese Han ethnicity. METHODS: Enrolled CHD patients (n = 367) underwent gene sequencing of ACE2 SNPs rs2074192, rs2285666, and rs2106809. Patients with pulmonary hypertension were further examined for detailed hemodynamics. RESULTS: Female heterozygous patients had worse pulmonary circulation hemodynamic parameters compared to those of homozygotes. Female CHD patients with the CCA (OR = 0.53, 95% CI: 0.32-0.88) or CCG (OR = 0.59, 95% CI: 0.35-0.99) haplotype had a lower risk of elevated pulmonary artery pressure. CONCLUSION: In female CHD patients, ACE2 SNPs are related to pulmonary circulation hemodynamics. Female CHD patients with the CCA and CCG haplotype had a lower risk of pulmonary hypertension.
No takes yet. Share an insight, caveat, or question.
Yang et al. (2023) conducted an observational in Congenital heart disease (n=367). ACE2 gene polymorphisms (CCA or CCG haplotype) vs. Other haplotypes was evaluated on Elevated pulmonary artery pressure (OR 0.53, 95% CI 0.32-0.88). Female congenital heart disease patients with the ACE2 CCA haplotype had a lower risk of elevated pulmonary artery pressure.
Synapse has enriched 10 related papers. Consider them for comparative context: