High-Sensitivity Cardiac Troponin T and Risk of Hypertension
Key result
Elevated baseline hs-cTnT is linked to ~31% higher risk of incident hypertension.
- HR 1.31
- 95% CI 1.07-1.61
- P<0.001
- n=6,516
Why the study?
The diagnosis of hypertension is often preceded by cardiac structural abnormalities, and it is unclear whether hs-cTnT can identify individuals at risk for hypertension or left ventricular hypertrophy.
Does elevated baseline hs-cTnT predict incident hypertension and left ventricular hypertrophy in individuals without baseline cardiovascular disease or hypertension?
Population
6516 ARIC Study participants free of prevalent hypertension and cardiovascular disease at baseline
Comparison
Baseline hs-cTnT categories ≥5 ng/L versus <5 ng/L
Design
Prospective cohort study
Follow-up
Maximum of 19.9 years for diagnosed hypertension, 6 years for visit-based hypertension and LVH
Authors
Discussion
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Member takes
Implication
May flag subclinical cardiac stress before hypertension; hypothesis-generating and should not yet change practice.
Study Design
Type
Cohort (n=6,516)
Multicenter
Yes
Structured PICO
Does elevated baseline hs-cTnT predict incident hypertension and left ventricular hypertrophy in individuals without baseline cardiovascular disease or hypertension?
P
Population
6,516 participants free of prevalent hypertension and cardiovascular disease at baseline, followed for a maximum of 19.9 years.
E
Exposure
Baseline high-sensitivity cardiac troponin T (hs-cTnT) levels ≥5 ng/L (categorized as 5 to 8 ng/L, 9 to 13 ng/L, and ≥14 ng/L)
C
Comparator
Baseline hs-cTnT <5 ng/L
O
Outcome
Incident diagnosed hypertension (defined by self-report of a diagnosis or medication use during a maximum of 19.9 years of follow-up) and incident visit-based hypertension (defined by self-report, medication use, or measured blood pressure >140/90 mm Hg over 6 years)surrogate
Main Result
Hazard Ratio: 1.31 (95% CI 1.07–1.61)
p-value: p=<0.001
Subclinical myocardial damage, as indicated by elevated hs-cTnT, precedes and predicts the development of incident hypertension and left ventricular hypertrophy in an ambulatory population.
Cite This Study
McEvoy et al. (2015) conducted a cohort in Free of prevalent hypertension and cardiovascular disease (n=6,516). High-sensitivity cardiac troponin T (hs-cTnT) vs. hs-cTnT <5 ng/L was evaluated on Incident diagnosed hypertension (HR 1.31, 95% CI 1.07-1.61, p=<0.001). Baseline high-sensitivity cardiac troponin T ≥14 ng/L was associated with an increased risk of incident diagnosed hypertension compared with <5 ng/L (HR 1.31; 95% CI 1.07-1.61; P for trend <0.001).