Key result
Higher mean blood pressure is linked to accelerated renal function decline, independent of age.
Why the study?
The study aimed to confirm that the rate of decline in renal function is inversely correlated with blood pressure in a normal population using longitudinal observations.
Is mean blood pressure associated with the rate of decline in renal function in a normal population?
Cohort
Is mean blood pressure associated with the rate of decline in renal function in a normal population?
Higher mean blood pressure and increasing age independently accelerate the decline of renal function in a normal population.
Supports BP management for renal preservation in general populations; hypothesis-generating and should not yet alter practice.
The purpose of this study was to confirm, using longitudinal observations in a normal population, that the rate of decline in renal function (creatinine clearance) is inversely correlated with blood pressure. The negative regression coefficients plotting individual rates of decline over time (Bcr) against mean blood pressures (MBP) were highly significant (p less than 0.001) for all subjects and subjects in category 3 (normals). Although the Bcr also decreases significantly with age and MBP increases with age suggesting this might be an age effect, a multiple regression analysis shows that both MBP and age as independent variables exert statistically significant effects on Bcr, the dependent variable.
No takes yet. Share an insight, caveat, or question.
Lindeman et al. (2008) conducted a cohort in Normal population. Mean blood pressure was evaluated on Rate of decline in renal function (creatinine clearance) (p=<0.001). Higher mean blood pressure was significantly associated with a faster rate of decline in renal function over time, independent of age (p<0.001).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: