Key result
Adding calcium to iodixanol nearly abolishes transient LVDP depression in isolated rat hearts.
Why the study?
The potential for iodixanol formulations to depress cardiac contractility during coronary angiography and the requirements for balanced calcium addition to maintain stable cardiac function were unclear.
Does adding calcium to isotonic iodixanol prevent depression of cardiac contractility in isolated perfused rat hearts?
Population
Isolated perfused rat hearts
Comparison
Iodixanol with added calcium vs iodixanol without added calcium
Design
Preclinical experimental study
Authors
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Balanced Ca addition mitigates LVDP depression in rat hearts; leaves open optimal iodixanol formulations for clinical use.
Does adding calcium to isotonic iodixanol prevent depression of cardiac contractility in isolated perfused rat hearts?
Adding specific, balanced amounts of calcium to isotonic iodixanol formulations can alleviate transient depression of cardiac contractility in a preclinical model.
Jynge et al. (1993) studied Cardiac contractility depression during coronary angiography. Iodixanol with added Calcium vs. Iodixanol in the absence of added Ca was evaluated on Changes in left ventricular developed pressure (LVDP). Adding 0.4 to 0.9 mM calcium to iodixanol almost abolished the transient depression in left ventricular developed pressure in isolated rat hearts.
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