Key result
Two-wavelength photoacoustic imaging improves ablation lesion detection to 97% accuracy over single-wavelength analysis.
Why the study?
A better assessment of lesion quality, depth, and continuity after catheter-based radiofrequency ablation for atrial fibrillation could improve procedural outcomes.
Does a two-wavelength photoacoustic imaging technique improve the diagnostic accuracy of detecting radiofrequency ablation lesions in atrial-wall tissue compared to single-wavelength imaging?
Does a two-wavelength photoacoustic imaging technique improve the diagnostic accuracy of detecting radiofrequency ablation lesions in atrial-wall tissue compared to single-wavelength imaging?
Absolute Event Rate: 97% vs 82%
A two-wavelength photoacoustic imaging technique significantly improves the in vitro detection accuracy of radiofrequency ablation lesions in atrial tissue compared to single-wavelength imaging.
Two-wavelength photoacoustic imaging detects ablation lesions in vitro; hypothesis-generating for AF ablation guidance, clinical validation required before practice change.
Catheter-based radiofrequency ablation for atrial fibrillation has long-term success in 60-70% of cases. A better assessment of lesion quality, depth, and continuity could improve the procedure's outcome. We investigate here photoacoustic contrast between ablated and healthy atrial-wall tissue in vitro in wavelengths spanning from 410 nm to 1000 nm. We studied single- and multi-wavelength imaging of ablation lesions and we demonstrate that a two-wavelength technique yields precise detection of lesions, achieving a diagnostic accuracy of 97%. We compare this with a best single-wavelength (640 nm) analysis that correctly identifies 82% of lesions. We discuss the origin of relevant spectroscopic features and perspectives for translation to clinical imaging.
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Iskander-Rizk et al. (2018) studied Atrial fibrillation. Two-wavelength photoacoustic imaging vs. Single-wavelength (640 nm) analysis was evaluated on Diagnostic accuracy for detection of ablation lesions. Two-wavelength photoacoustic imaging achieved a diagnostic accuracy of 97% for detecting ablation lesions in vitro, compared to 82% with single-wavelength (640 nm) analysis.
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