Key result
LA strain discriminates diastolic dysfunction better than LAVI, achieving an AUC of ~0.82.
Why the study?
The frequency of left ventricular diastolic dysfunction is overestimated by earlier recommendations, and the potential of adding left atrial strain to current guidelines needed exploration.
Does the addition of left atrial strain to the 2016 guidelines improve the detection and classification of left ventricular diastolic dysfunction in patients with heart failure?
Observational (n=147)
Does the addition of left atrial strain to the 2016 guidelines improve the detection and classification of left ventricular diastolic dysfunction in patients with heart failure?
Effect estimate: AUC 0.816
Incorporating left atrial strain into the 2016 diastolic dysfunction guidelines improves diagnostic accuracy and reduces the rate of indeterminate diastolic function in heart failure patients.
Supports prioritizing left atrial strain in diastolic assessment; extends diagnostic accuracy data beyond volume index in Level 1 evidence.
Background: The frequency of left ventricular diastolic dysfunction (DD) is overestimated by earlier recommendations. We compared the 2009 and 2016 guidelines regarding the detection of DD and explored the potential of adding left atrial (LA) strain to the current guideline. Methods: Consecutive patients with heart failure were enrolled. All the patients were examined using 2-dimensional speckle-tracking echocardiography (2D-STE) and tissue Doppler imaging. DD was evaluated in terms of E/eʹ, eʹ velocity, E, A, tricuspid regurgitation velocity, LA volume, and LA strain. Results: This study evaluated 147 patients (101 males, 68.7%) at a mean age of 54.73±14.42 years. LA strain decreased with increasing grades of DD in both guidelines. The rate of reclassification between the 2 guidelines was 41%. The detection rate of normal diastolic function increased after the implementation of the 2016 guideline. LA strain discriminated individuals with normal diastolic function from those with DD more accurately than did LA volume index (area under the curve [AUC] =0.816 vs AUC=0.759, respectively). When LA strain <23% was incorporated into the 2016 guideline, 2 out of 4 patients with indeterminate diastolic function were reclassified as normal and 2 patients as grade I DD. The rate of reclassification was 4.1% after the addition of LA strain to the current guideline (κ=0.939, P<0.001). Conclusion: This study showed that the current guideline detected lower rates of DD than did the earlier recommendations. Furthermore, the incorporation of LA strain into the current guideline resulted in lower rates of indeterminate diastolic function.
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Samiei et al. (2021) conducted an observational in Heart failure (n=147). Left atrial strain vs. Left atrial volume index was evaluated on Discrimination of normal diastolic function from diastolic dysfunction (AUC 0.816). Left atrial strain discriminated individuals with normal diastolic function from those with diastolic dysfunction more accurately than left atrial volume index (AUC 0.816 vs 0.759).
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