September 1, 1992Echocardiography
Intravascular Ultrasound Imaging of Arterial Wall Architecture
Key result
IVUS three-layer appearance reflects beam angle rather than true arterial histologic layers.
- n=9
Why the study?
Controversy exists whether the three-layer appearance of the arterial wall on IVUS correctly reflects the histologic structures of the intima, media, and adventitia.
Does the three-layer appearance on intravascular ultrasound correctly reflect the histologic structures of the arterial wall?
Comparison
IVUS imaging vs histologic examination
Design
Experimental study
Authors
Discussion
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Implication
IVUS three-layer appearance needs histologic validation before clinical use; leaves open accurate intima-media-adventitia correlation.
Structured PICO
Does the three-layer appearance on intravascular ultrasound correctly reflect the histologic structures of the arterial wall?
P
Population
Experimental and clinical study evaluating the three-layer appearance of the arterial wall using IVUS on plastic cylinders, animal vessels, human arterial segments, and 9 patients with aortic dissection.
E
Exposure
Intravascular ultrasound (IVUS)
C
Comparator
Histologic examination
O
Outcome
Correspondence between the IVUS three-layer appearance and histologic structures (intima, media, adventitia)surrogate
The three-layer appearance of the arterial wall on IVUS is an acoustic artifact rather than a true representation of histologic layers.
Cite This Study
Ge et al. (1992) studied Aortic dissection (n=9). Intravascular ultrasound (IVUS) vs. Histologic examination was evaluated on Correspondence between IVUS three-layer appearance and histologic structures. Intravascular ultrasound imaging produced a three-layer appearance of the arterial wall that did not correspond to histologic layers, but rather depended on the ultrasound beam being perpendicular.