Key result
Prolonged total isovolumic time combined with broad QRS predicts CRT response with 88% specificity.
Why the study?
Standard segmental Doppler echocardiographic measures of ventricular dyssynchrony are controversial in predicting response to CRT in late stage heart failure patients.
Does total isovolumic time combined with QRS duration improve the prediction of response to cardiac resynchronization therapy in heart failure patients?
Observational (n=103)
Does total isovolumic time combined with QRS duration improve the prediction of response to cardiac resynchronization therapy in heart failure patients?
Odds Ratio: 0.878 (95% CI 0.802–0.962)
p-value: p=0.005
Combining total isovolumic time with QRS duration significantly improves the specificity of predicting which heart failure patients will respond to cardiac resynchronization therapy.
No takes yet. Share an insight, caveat, or question.
May enhance CRT response prediction specificity when added to QRS; observational data leave open need for prospective validation.
Bajraktari et al. (2013) conducted an observational in Heart failure (n=103). Total isovolumic time was evaluated on Response to cardiac resynchronization therapy (reduction in NYHA class and NT-proBNP) (OR 0.878, 95% CI 0.802-0.962, p=0.005). Prolonged total isovolumic time independently predicted response to cardiac resynchronization therapy (OR 0.878, p=0.005), and combining it with broad QRS duration improved specificity to 88%.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: