Key result
Prolonged total isovolumic time linked to ~12% lower odds of CRT response.
Why the study?
The additional value of global left ventricular dyssynchrony markers in predicting CRT response in heart failure patients was unclear.
Does the combination of total isovolumic time and QRS duration predict clinical response to cardiac resynchronization therapy in heart failure patients?
Observational (n=103)
Does the combination of total isovolumic time and QRS duration predict clinical response to cardiac resynchronization therapy in heart failure patients?
Effect estimate: 0.878 (95% CI 0.802-0.962)
p-value: p=0.005
Combining echocardiographic total isovolumic time with QRS duration improves the specificity of predicting clinical response to cardiac resynchronization therapy.
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May refine observational CRT selection; leaves open prospective validation before practice change.
Bajraktari et al. (2014) conducted an observational in Heart failure (n=103). Prolonged total isovolumic time (t-IVT) was evaluated on Response to CRT (reduction in NYHA class) (0.878, 95% CI 0.802-0.962, p=0.005). Prolonged total isovolumic time independently predicted clinical response to cardiac resynchronization therapy (estimate 0.878; 95% CI 0.802-0.962; P=0.005).
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