Key result
Active rheumatoid arthritis is linked to significantly impaired myocardial work indices and longitudinal strain.
Why the study?
Early cardiac damage is common but usually subclinical in rheumatoid arthritis patients, necessitating non-invasive methods for early detection and treatment of cardiac damage in autoimmune diseases.
Does rheumatoid arthritis disease activity correlate with impaired myocardial work assessed by LV-PSL in patients with preserved LVEF?
Observational (n=91)
No
Does rheumatoid arthritis disease activity correlate with impaired myocardial work assessed by LV-PSL in patients with preserved LVEF?
LV-PSL technology can effectively detect subclinical myocardial work impairment in RA patients with preserved LVEF, revealing that higher disease activity correlates with reduced myocardial work.
Answers are grounded in this paper and cite their sources.
May support LV-PSL screening for subclinical impairment in active RA with preserved LVEF; hypothesis-generating for prognostic and therapeutic implications.
BACKGROUND: Early cardiac damage is very common in RA patients, but it is usually subclinical. Therefore, finding a non-invasive method for the early detection and treatment of cardiac damage in autoimmune diseases is particularly important.diac dam RA ，。，。 OBJECTIVE: To evaluate left ventricular function changes in rheumatoid arthritis (RA) patients with preserved left ventricular ejection fraction (LVEF) using left ventricular pressure-strain loop (LV-PSL) technology and to explore the correlation between myocardial work (MW) and disease activity.- （LV-PSL） （LVEF） （RA） ， （MW） 。 METHODS: A total of 62 RA patients with preserved LVEF, treated at Wujin Hospital Affiliated with Jiangsu University from January 2021 to September 2023, were included. Patients were categorized into low (25), medium (18), and high (19) disease activity groups based on the 28 joint disease activity score (DAS28). A control group of 29 healthy individuals was also established. LV-PSL technology assessed left ventricular global longitudinal strain (GLS) and MW parameters: global constructive work (GCW), global wasted work (GWW), global work index (GWI), and global work efficiency (GWE). Correlations between MW parameters, GLS, LVEF, and DAS28 scores were analyzed. 2021 1 20239 62 LVEF RA 。 28 （DAS28） （25） 、 （18） （19） 。 29 。LV-PSL （GLS） MW ： （GCW）、 （GWW）、 （GWI） （GWE）。 MW 、 GLS 、 LVEF DAS28 。 RESULTS: There were no significant differences in general data between study and control groups (p > 0.05). However, laboratory indicators (RF, CRP, ESR) showed significant differences (p < 0.05). GWI, GCW, GWE, and GLS were significantly lower in the high disease activity group compared to controls (p < 0.05). GWI, GCW, and GWE were positively correlated with LVEF and absolute GLS, while GWW correlated negatively with LVEF (p < 0.05). （p > 0.05）。， （RF、CRP、ESR） （p < 0.05）。， GWI、GCW、GWE GLS （p < 0.05）。GWI、GCW GWE LVEF GLS ， GWW LVEF （p < 0.05）。 （p > 0.05）。， （RF、CRP、ESR） （p < 0.05）。， GWI、GCW、GWE GLS （p < 0.05）。GWI、GCW GWE LVEF GLS ， GWW LVEF （p < 0.05）。 CONCLUSION: RA disease activity is closely associated with impaired myocardial work. LV-PSL technology effectively monitors myocardial function abnormalities in RA patients, providing valuable insights for clinical management. Key Points • Myocardial work is significantly impaired in RA patients with high disease activity. • Left ventricular pressure-strain loop (LV-PSL) technology effectively assesses cardiac function in this patient population. • Increased disease activity correlates with reduced myocardial work parameters.
No takes yet. Share an insight, caveat, or question.
Yu et al. (2025) conducted an observational in Rheumatoid arthritis with preserved left ventricular ejection fraction (n=91). Rheumatoid arthritis disease activity vs. Healthy individuals was evaluated on Myocardial work parameters (GWI, GCW, GWW, GWE) and global longitudinal strain (GLS) (p=< 0.05). High rheumatoid arthritis disease activity was associated with significantly lower global work index, constructive work, work efficiency, and longitudinal strain compared to controls (p < 0.05).
Synapse has enriched 10 related papers. Consider them for comparative context: