November 1, 1998Pacing and Clinical Electrophysiology
T Wave Complexity in Patients with Hypertrophic Cardiomyopathy
Key result
Higher ECG T-wave complexity links to hypertrophic cardiomyopathy and correlates with syncope.
- P<0.0001
- n=184
Why the study?
The ability of T wave complexity assessed by principal component analysis to differentiate HCM patients from normal subjects and its prognostic importance in HCM was unclear.
Does T wave complexity assessed by PCA differentiate patients with hypertrophic cardiomyopathy from normal subjects and associate with arrhythmogenic risk factors like syncope?
Population
112 patients with hypertrophic cardiomyopathy and 72 healthy subjects
Comparison
HCM patients vs healthy subjects; HCM patients with syncope vs without syncope
Design
Case-control study
Authors
Discussion
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Member takes
Implication
May flag repolarization abnormalities and syncope risk in HCM; leaves open its utility for prospective arrhythmic risk stratification.
Study Design
Type
Case-Control (n=184)
Structured PICO
Does T wave complexity assessed by PCA differentiate patients with hypertrophic cardiomyopathy from normal subjects and associate with arrhythmogenic risk factors like syncope?
P
Population
184 participants, comprising 112 patients with hypertrophic cardiomyopathy and 72 healthy controls aged ≥15 years, evaluated for T wave complexity using principal component analysis.
E
Exposure
T wave complexity assessment by principal component analysis (PCA) using standard 12-lead ECGs
C
Comparator
Healthy subjects (for diagnostic comparison) and HCM patients without syncope or nonsustained ventricular tachycardia (for prognostic comparison)
O
Outcome
PCA ratio difference between HCM patients and normal controlssurrogate
Main Result
Absolute Event Rate: 23.9% vs 16.1%
p-value: p=< 0.0001
T wave complexity assessed by PCA is significantly elevated in patients with hypertrophic cardiomyopathy and is associated with a history of syncope, suggesting it may serve as a marker for abnormal repolarization and arrhythmogenic risk.
Cite This Study
Yi et al. (1998) conducted a case-control in Hypertrophic Cardiomyopathy (n=184). Hypertrophic cardiomyopathy vs. Healthy subjects was evaluated on PCA ratio (p=< 0.0001). T wave complexity assessed by PCA ratio was significantly higher in patients with hypertrophic cardiomyopathy than in healthy controls (23.9% vs 16.1%, P<0.0001) and was associated with syncope.