Key result
Oral captopril prevents stress-induced blood pressure elevation in borderline hypertensive rats.
Why the study?
The involvement of the renin-angiotensin system in the development of stress-induced hypertension in borderline hypertensive rats was unclear.
Does captopril prevent the development of stress-induced hypertension in borderline hypertensive rats?
Population
8- and 9-week-old borderline hypertensive rats
Comparison
Oral captopril with AJS vs AJS without captopril vs captopril without AJS vs neither AJS nor captopril
Design
Experimental study with four groups of rats
Follow-up
10 days
Authors
Loading...
Captopril blocked stress-induced hypertension in BHR; leaves open whether RAS inhibition attenuates behavioral stress effects on BP in humans.
Does captopril prevent the development of stress-induced hypertension in borderline hypertensive rats?
In a rat model, captopril prevented the development of stress-induced hypertension, suggesting a role for the renin-angiotensin system in this process.
Coste et al. (1995) studied Borderline hypertension. Oral captopril vs. No captopril was evaluated on Mean arterial pressure. Oral captopril prevented the significant elevation of blood pressure caused by 10 days of air-jet stress in borderline hypertensive rats.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: