Key result
Calcium increases myocardial tension by ~26% while verapamil exerts opposite mechanical effects.
Why the study?
The effects of pharmacologically induced changes in myocardial properties on diastolic mitral valve mechanics were not well understood.
Population
Five open-chest dogs with induced complete atrioventricular block
Comparison
Calcium vs verapamil vs control on myocardial tension and mitral valve reopening time
Design
Experimental study with programmed pacing and echocardiographic assessment
Authors
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These tension and timing shifts in isolated tissue warrant no clinical change; leaves open in vivo mitral valve effects.
Absolute Event Rate: 30% vs 23.8%
p-value: p=<0.005
Michelson et al. (1986) studied this question. Calcium vs. Control was evaluated on Myocardial tension (g/cm2) (p=<0.005). Calcium significantly increased myocardial tension and prolonged mitral reopening time, whereas verapamil decreased myocardial tension and shortened mitral reopening time compared with the control state.
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