Key result
Biopsy-proven acute myocarditis linked to ~125% higher rate of damaging genetic variants.
Why the study?
The variability in susceptibility to myocarditis after similar viral exposure is incompletely explained by known factors, prompting investigation into host genetic susceptibility.
Absolute Event Rate: 16.2% vs 7.2%
[Figure: see text]
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Cooper et al. (2021) conducted an editorial in Acute myocarditis (n=585). Biopsy-proven acute myocarditis vs. Matched controls without cardiomyopathy or neuromuscular disease was evaluated on Rate of damaging genetic variants (DVs). The rate of damaging genetic variants was significantly higher in patients with biopsy-proven acute myocarditis (16.2%) compared to matched controls (7.2%).
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