Phenethoxy Derivatives with Anti-inflammatory Activities from the Betelnut Endophytic Trichoderma asperellum G10

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Eight new phenethoxy derivatives, trichoasperellins A–H ( 1 – 8 ), were isolated from the endophytic fungus Trichoderma asperellum G10 isolated from the medicinal plant Areca catechu L. The structures of these compounds were elucidated from spectroscopic data, J -based configurational analysis, and Mosher’s methods. Compounds 1 – 4 and 6 – 8 bear one or two multioxidized C 7 moieties with the same carbon skeleton. The carbon skeletons of compounds 6 – 8 are new, all containing three moieties connected via two acetal carbons similar to those of disaccharide glycosides. Compound 4 inhibited nitric oxide production with an IC 50 value of 48.3 μM, comparable to that of the positive control indomethacin (IC 50, 42.3 μM).