Key result
Prior Kawasaki disease is linked to subclinical LV dysfunction with higher myocardial performance index vs. controls.
Why the study?
Long-term ventricular function after Kawasaki disease is unclear despite normal conventional echocardiography findings.
Does tissue Doppler echocardiography detect subclinical ventricular dysfunction in children with a history of Kawasaki disease compared to healthy controls?
Cohort (n=54)
No
Does tissue Doppler echocardiography detect subclinical ventricular dysfunction in children with a history of Kawasaki disease compared to healthy controls?
Mean Difference: 0.021
Absolute Event Rate: 0.518% vs 0.497%
p-value: p=0.01
Tissue Doppler-derived Myocardial Performance Index can identify subclinical global ventricular dysfunction in children with a history of Kawasaki disease, even when conventional echocardiographic parameters appear normal.
MPI may flag subclinical dysfunction in post-Kawasaki children despite normal conventional echo; cross-sectional association leaves open need for longitudinal validation.
Objective: To evaluate ventricular functions using tissue Doppler echocardiography in long-term followup of children with Kawasaki disease after acute phase treatment.Method: Thirty patients (16 boys, 14 girls; mean age 4.41±3.07years) treated for Kawasaki disease at our unit between September 1999 and June 2009 were compared with 24 healthy controls of similar age and gender.All subjects underwent standard and tissue Doppler echocardiographic evaluations.Systolic (S') and diastolic (E', A') myocardial velocities were measured from left ventricular basal segments, and myocardial performance indices (MPIs) were calculated.Results: Mean follow-up period was 24.53±19.06months.Coronary artery involvement occurred in 13 (43.3%)patients during acute phase, but no aneurysms persisted during follow-up period.Standard echocardiographic parameters including left ventricular ejection fraction, shortening fraction, mitral flow velocities, and aortic velocity showed no significant differences between groups (p>0.05).Tissue Doppler echocardiography measurements of lateral wall velocities and time intervals were comparable.However, left ventricular MPIs were significantly higher in patients (0.518±0.028) compared to controls (0.497±0.028) (p=0.01).Conclusions: Despite normal conventional echocardiography findings after average 2-year follow-up period, elevated myocardial performance indices indicated subclinical global ventricular dysfunction in children with Kawasaki disease.Tissue Doppler-derived MPI represents a valuable non-invasive parameter for long-term cardiac surveillance in these patients.
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Bulut et al. (2026) conducted a cohort in Kawasaki disease (n=54). History of Kawasaki disease vs. Healthy controls was evaluated on Left ventricular myocardial performance index (MPI) (p=0.01). Children with a history of Kawasaki disease demonstrated subclinical global ventricular dysfunction, indicated by a significantly higher left ventricular myocardial performance index compared to healthy controls (0.518 vs 0.497).
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