Effects of benidipine hydrochloride on antioxidant enzyme activity in stroke-prone spontaneous hypertensive rats (SHR-SP)

Q: What is the clinical evidence from this study?

Population: Hypertension with cerebral stroke (stroke-prone spontaneously hypertensive rats model). Intervention: Benidipine hydrochloride vs. Triple therapy (hydralazine, reserpine, and hydrochlorothiazide), untreated SHR-SP, and normotensive WKY rats. Primary outcome: Renal cortical and medullary intrinsic antioxidant enzyme (AOE) activity, specifically glutathione peroxidase (GSH-Px) activity.

Q: What does this research mean for the field?

Benidipine hydrochloride significantly improves renal intrinsic glutathione peroxidase activity, reduces urinary albumin excretion, and improves creatinine clearance in stroke-prone spontaneously hypertensive rats. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Ichiyu Shou; Li Ning Wang; Yutaka Takahashi; Mitsumine Fukui; Yasuhiko Tomino

doi:10.1002/(sici)1098-2825(1997)11:3<158::aid-jcla7>3.0.co;2-6

January 1, 1997Journal of Clinical Laboratory AnalysisOpen Access

Effects of benidipine hydrochloride on antioxidant enzyme activity in stroke-prone spontaneous hypertensive rats (SHR-SP)

View Full Paper

Ask AI

Bookmark

Share

Key result

Benidipine improves renal antioxidant activity, albuminuria, and creatinine clearance in hypertensive rats.

Why the study?

The effects of benidipine hydrochloride or triple therapy on renal cortical and medullary intrinsic antioxidant enzyme activity in stroke-prone spontaneously hypertensive rats required evaluation.

Key Points

To evaluate the effects of benidipine hydrochloride and triple therapy on renal cortical and medullary antioxidant enzyme activity and renal function in stroke-prone spontaneously hypertensive rats.
Assessed renal cortical and medullary intrinsic antioxidant enzyme activity in stroke-prone spontaneously hypertensive rats (SHR-SP) treated with benidipine hydrochloride or triple therapy (hydralazine, reserpine, and hydrochlorothiazide).
Compared untreated SHR-SP with normotensive Wistar Kyoto (WKY) reference rats.
Measured urinary albumin excretion, creatinine clearance, and histological glomerular sclerosis index by light microscopy.
Renal intrinsic glutathione peroxidase (GSH-Px) activity was significantly decreased in untreated SHR-SP compared to normotensive WKY control rats.
Benidipine hydrochloride therapy significantly improved renal GSH-Px activity, urinary albumin excretion, and creatinine clearance in SHR-SP.
Glomerular sclerosis index demonstrated slight improvement in SHR-SP following benidipine hydrochloride administration based on light microscopic evaluation.

PICO

P

Population

Stroke-prone spontaneously hypertensive rats (SHR-SP) and normotensive Wistar Kyoto (WKY) reference rats evaluated as an animal model for human essential hypertension with cerebral stroke.

I

Intervention / Comparator

Benidipine hydrochloride vs Triple therapy (hydralazine, reserpine, and hydrochlorothiazide), untreated SHR-SP, and normotensive WKY rats

O

Primary Outcome

Renal cortical and medullary intrinsic antioxidant enzyme (AOE) activity, specifically glutathione peroxidase (GSH-Px) activity

Ask about this paper

Answers are grounded in this paper and cite their sources.

Implication

Suggests antioxidant renoprotection in hypertensive rat models; leaves open human translation.

Abstract

Effects of benidipine hydrochloride or triple therapy (hydralazine, reserpine, and hydrochlorothiazide) on renal cortical and medullary intrinsic antioxidant enzyme (AOE) activity were evaluated in stroke-prone spontaneously hypertensive rats (SHR-SP) as an animal model for human essential hypertension with cerebral stroke. This study showed a significant decrease of renal intrinsic glutathione peroxidase (GSH-Px) activity in untreated SHR-SP. Renal GSH-Px activity in untreated SHR-SP was significantly lower than that in Wister Kyoto rats (WKY) as a normotensive reference strain. GSH-Px activity in SHR-SP was significantly improved after benidipine hydrochloride therapy. Levels of urinary albumin excretion or creatinine clearance (Ccr) in SHR-SP were also improved after the therapy. Glomerular sclerosis index was slightly improved in SHR-SP treated with benidipine hydrochloride according to light microscopic analysis. It appears that hypertension may influence the renal intrinsic GSH-Px activity, albuminuria, and Ccr in SHR-SP. Thus it is indicated that control of blood pressure may improve the GSH-Px activity in SHR-SP.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Shou et al. (1997) studied Hypertension with cerebral stroke (stroke-prone spontaneously hypertensive rats model). Benidipine hydrochloride vs. Triple therapy (hydralazine, reserpine, and hydrochlorothiazide), untreated SHR-SP, and normotensive WKY rats was evaluated on Renal cortical and medullary intrinsic antioxidant enzyme (AOE) activity, specifically glutathione peroxidase (GSH-Px) activity. Benidipine hydrochloride significantly improved renal intrinsic glutathione peroxidase activity, urinary albumin excretion, and creatinine clearance in stroke-prone spontaneously hypertensive rats.

synapsesocial.com/papers/6ae8c110944418dc5068babf https://doi.org/10.1002/(sici)1098-2825(1997)11:3<158::aid-jcla7>3.0.co;2-6

View Full Paper

Ask AI

Bookmark

Share

Effects of benidipine hydrochloride on antioxidant enzyme activity in stroke-prone spontaneous hypertensive rats (SHR-SP)

Key Points

PICO

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Effects of benidipine hydrochloride on antioxidant enzyme activity in stroke-prone spontaneous hypertensive rats (SHR-SP)

Key Points

PICO

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Keep reading

Keep reading