Key result
Type 1 diabetes and higher weight are associated with increased carotid intima-media thickness.
Why the study?
This study aimed to evaluate subclinical atherosclerosis and its related factors in young patients with type 1 diabetes and healthy peers.
Are type 1 diabetes, weight, and HDL cholesterol levels associated with increased carotid intima-media thickness in young patients compared to healthy peers?
Cross-Sectional (n=119)
Are type 1 diabetes, weight, and HDL cholesterol levels associated with increased carotid intima-media thickness in young patients compared to healthy peers?
In young patients with well-controlled type 1 diabetes, body weight and low HDL cholesterol (especially <=47.5 mg/dL in males) are key determinants of increased carotid intima-media thickness.
Answers are grounded in this paper and cite their sources.
Should not yet change practice in young T1D; leaves open whether weight or HDL modification affects cIMT progression.
The aim of this study was to evaluate subclinical atherosclerosis and related factors in young type 1 diabetes (T1D) patients and healthy peers. Carotid intima-media thickness (cIMT) and anthropometric/laboratorial data were obtained for 83 T1D patients (mean age 19.5 ± 4.0 years, disease duration 9.8 ± 4.8 years) and for 36 matched healthy subjects. Considering all the participants as one group, male sex (p = 0.008), weight (p = 0.016) and T1D (p < 0.001) were positively associated with a higher cIMT. High-density lipoprotein (HDL) (p = 0.036) was negatively associated with cIMT in T1D. In the male T1D patients, HDL ≤47.5 mg/dL had a sensitivity of 87.5% and specificity of 57% (p = 0.035) in detecting those belonging to a higher cIMT tercile. In conclusion, weight and T1D were associated with increased cIMT. HDL levels ≤47.5 mg/dL were related to a higher cIMT in male T1D patients.
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Pinto et al. (2014) conducted a cross-sectional in Type 1 diabetes and subclinical atherosclerosis (n=119). Type 1 diabetes, weight, and HDL cholesterol levels vs. Matched healthy peers was evaluated on Carotid intima-media thickness (cIMT) (p=<0.001). Type 1 diabetes (p<0.001) and weight (p=0.016) were positively associated with carotid intima-media thickness, while HDL <=47.5 mg/dL predicted higher cIMT in males (p=0.035).
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