Key result
Efonidipine prevents systolic BP rise and cardiorenal injury in SHRs but fails to stop prostatic lesions.
Why the study?
The effect of hypertension on the development of prostatic abnormalities in spontaneously hypertensive rats (SHRs) required examination using the calcium antagonist efonidipine hydrochloride.
Does efonidipine hydrochloride prevent the development of prostatic abnormalities and elevation of systolic blood pressure in spontaneously hypertensive rats?
Does efonidipine hydrochloride prevent the development of prostatic abnormalities and elevation of systolic blood pressure in spontaneously hypertensive rats?
Answers are grounded in this paper and cite their sources.
In spontaneously hypertensive rats, efonidipine hydrochloride prevents hypertension and target organ damage in the heart and kidneys, but does not prevent prostatic epithelial abnormalities, suggesting these prostatic lesions are not a direct consequence of hypertension.
The hypertensive effect on the development of the prostatic abnormality in spontaneously hypertensive rats (SHRs) was examined using Efonidipine hydrochloride, a calcium antagonist. The control SHRs were given a high sodium and potassium diet (SP-diet) alone, and the treated SHRs were given a SP-diet with 0.15% Efonidipine hydrochloride from 8 to 28 weeks of age. The systolic blood pressure (SBP) in the control SHRs increased with age, while the elevation of SBP was significantly prevented in the treated SHRs. Light-microscopically, the prostatic lesion was observed both in the control and treated SHRs. The glandular lumen was narrowed with papillary protrusions, and the epithelium was composed of tall columnar epithelial cells. However, hypertension-induced complications in kidneys and hearts were not observed in the treated SHRs. These results suggested that the prostatic abnormality of SHRs might not be the consequent lesions upon hypertension.
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Furukawa et al. (1994) studied Hypertension and prostatic abnormality in spontaneously hypertensive rats (SHRs). Efonidipine hydrochloride vs. High sodium and potassium diet (SP-diet) alone was evaluated on Development of prostatic abnormality and systolic blood pressure (SBP) elevation. Efonidipine hydrochloride prevented systolic blood pressure elevation and renal/cardiac complications in SHRs, but did not prevent prostatic lesions.
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