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Genetic cosmeceuticals powered by nanotechnology offer a new path to customized anti-ageing skincare. Recent developments in nano-formulations have enabled precise, effective delivery to skin cells anti-ageing genetic elements, such as the SIRT1 and FOXO3 genes, which are essential for controlling cellular senescence and promoting skin regeneration. Nanocarriers such as lipid nanoparticles, polymeric nanoparticles, and exosomes shield genetic payloads from degradation and allow for regulated intracellular release, and yet their surface functionalization improves targeting of dermal fibroblasts and keratinocytes and minimizes off-target effects. This literature review aimed to analyze current anti-aging therapy options in the context of their efficacy and to examine the possibilities for newer genetic and nanotech anti-aging treatment options. Additionally covered is the synergistic function of nano-formulations in reducing oxidative stress and enhancing skin health when paired with growth factors and antioxidants. All things considered, genetic cosmeceuticals driven by nanotechnology present a paradigm shift toward targeted, minimally invasive, and customized anti-aging treatments.
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Chauhan et al. (2026) studied this question.
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