July 15, 2025

Supplementary Figure 7 from Large-scale Characterization of Orthotopic Cell Line–Derived Xenografts Identifies TGFβ Signaling as a Key Regulator of Breast Cancer Morphology and Aggressiveness

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Discussion

Analysis identifies tgfβ signaling as essential for breast cancer morphology and aggressiveness in mind-cdx models.

Main finding reveals tgfβ signaling significantly affects breast cancer morphology and aggressiveness.
In-depth characterization using mind-cdx models illustrates the dynamic nature of cancer cell behavior.
The approach involves large-scale analysis to connect cellular signaling to cancer progression.
Findings advance understanding of breast cancer, highlighting potential targets for therapeutic strategies.

Lutz et al. (2025) studied this question.

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