July 15, 2025

Supplementary Figure 1 from Large-scale Characterization of Orthotopic Cell Line–Derived Xenografts Identifies TGFβ Signaling as a Key Regulator of Breast Cancer Morphology and Aggressiveness

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Supplementary figure identifies TGFβ signaling's role in breast cancer morphology and aggressiveness, suggesting potential therapeutic targets.

Characterization of orthotopic cell line-derived xenografts helps understand breast cancer behavior.
TGFβ signaling is identified as a significant regulator of breast cancer morphology and aggressiveness.
The study utilizes cell lines and tumor outgrowths to uncover important biological insights.
Findings highlight TGFβ's role, indicating it could be a target for future breast cancer therapies.

Lutz et al. (2025) studied this question.

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Supplementary figure identifies TGFβ signaling's role in breast cancer morphology and aggressiveness, suggesting potential therapeutic targets.