July 15, 2025

Supplementary Figure 14 from Large-scale Characterization of Orthotopic Cell Line–Derived Xenografts Identifies TGFβ Signaling as a Key Regulator of Breast Cancer Morphology and Aggressiveness

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Discussion

Figure reveals tumor subtype is unchanged by TGF-beta pathway modifications in breast cancer, highlighting its role in morphology.

TGF-beta signaling shows a significant impact on breast cancer morphology and aggressiveness.
Despite pathway modifications, tumor subtype remains unaffected, suggesting stable characteristics.
Analysis utilizes orthotopic cell line-derived xenografts to study breast cancer properties.
Results indicate the need for further exploration of TGF-beta's role in cancer development and treatment.

Lutz et al. (2025) studied this question.

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